Fortunately they are fairly placid, their venom is a neurotoxin by definition, but fairly mild. According to people who annoyed a Golden Orb spider enough for it to bite them it's not much worse than a bee sting. I cannot comment because I,ve never been bitten by one - and do not plan to be. I also can't comment on bee stings because as a result of a near death experience when I was 18 months old, I am immune to bees and paper wasps - they worry me to the same extent as sand flies. I am however not immune to Hornets - found that out when one flew through my open visor and stung me on the face - 24 hours before the swelling went down enough to wear a helmet - Hornets hurt!