Yes you should always start the mixture adjustment from the baseline setting. Gently turn in the screw until it stops and turn out by the specified amount. From that base line setting Turning further out richens the mixture and turning in weakens it.
If the engine doesn't idle reasonably well at the baseline setting there is usually something else wrong with the carb.
The enrichers are completely independent of the main carb and have no interaction with the idle mixture adjustment.
To be certain of your baseline setting for the mixture screw check your carb model no against this list.
1/2 turn
64/28/201, 64/28/202, 64/28/301, 64/28/302, 64/28/303, 64/28/304, 64/32/203, 64/32/204, 64/32/307, 64/32/308, 64/32/347, 64/32/348, 64/32/201 (US), 64/32/202 (US), 64/32/223, 64/32/224, 94/40/107, 94/40/108
3/4 turn
64/32/305 (UK), 64/32/306 (UK), 64/32/321, 64/32/322, 64/32/325, 64/32/326, 64/32/335, 64/32/336, 64/32/349, 64/32/350, 64/32/351, 64/32/352, 64/32/353, 64/32/354, 64/32/357, 64/32/358
1/2 - 1 turn
64/32/9, 64/32/10, 64/32/11, 64/32/12, 64/32/13, 64/32/14, 64/32/201 (UK), 64/32/202 (UK)
[edit]
1 turn
64/32/19, 64/32/20, 94/40/109, 94/40/110, 94/40/113, 94/40/114