I've had my '81 R65 since January, '81 .
I lived in the Chicago area at the time and 5% ethanol was in the fuel supply .
I averaged 45 mpg then, speed limits on the rural highways was 55 mph, I could squeeze an occasional 50-52 mpg, with all interstate highway type riding for a full tank .
I moved to Phoenix in October, '93, there was MTBE in the fuel instead of ethanol, I was getting a consistent 45 -50 mpg then, still 55 mph highway speeds .
10% ethanol was added to the fuel supply and speed limit increased to 75 mph on rural highways about 12 years ago, fuel consumption is now at 38-40 mpg, I hit reserve around 190-200 miles now .
Increased speed and alcohol don't make a good combination for fuel consumption .
I even replaced the main jets on the '81 R65, from 143, to I think 135 or 137 and saw no difference in fuel usage .
Get alcohol out of the fuel, and back into beer, where it belongs !!!!!!!!!!!

My first suggestion, would be to replace the needle jet, it takes a beating from the needle .
Check the float level and condition of the float needle valve, it has a rubber tip and gets hardened with age .
Then a full carb synchronization .