That said, I'm ready to toss this one off a bridge. I've got a profound lack of acceleration (worse when cold) that would indicate a too rich mixture, but I have the screws set at the rec setting (half turn). FULL DISCLOSURE: I went up to a 150 on the main jet...
If "the screws" you're speaking of are the air mixture screws on the bottom of the carb body, you're
screwing in the wrong place.

The small brass ones are the Idle Air Mixture screws; idle being the operative word.
Confirm the enrichment bodies lever arms are fully closing. These little "choke" assemblies are actually mini-carburetors. if the enrichment levers are still partially open, you will definitely have an over-rich mixture. Also check cable length to the enrichers. Give just a hair of slack.
Your main jet does not come into full play until the engine revs are WFO. What is controlling the mid-range -where most of your riding is done- is the needle jet and the needle's position plus the carb slide's cutaway.
If the bike was mine, I'd first check that the enricheners are truly off. Second, I'd confirm the needle jet size, it's cleanliness, the cleanliness of the atomizer assembly and the correct position of the needles.
Remain calm and carby on.