I have heard and written about this at length, various tuners local to me - who will quite happily tune up an R65 to a larger capacity (eg up 800cc), higher compression ratio, differnet cam, twin plugs, gas flowing, mikunis etc. All of them are respected tuners (Jim Cray in Kent, Defazio in Frome and Andrew Sexton in Warwickshire) None of these tuners have any issue with tuning R65's and they all do it slightly differently. They all guarrantee their work, to a point. The crank is as strong in an R65 as any other boxer.
However, best results are attained with a post 81 engines with all alloy barrels. And there is talk of the post 81 engines having better oilways in the crank area. How true this is, I do no know having never pulled mine out to compare.
However, somebody, somewhere, has had a bad experience and has been heavily quoted on the interweb. So much so that it is now written in 'folklore' and every knows that you should never tune an R65 - but nobody can tell you why.
I have had a long conversation with a chap in Ireland (who I bought my wire wheels off) who had a souped up R65, and he said he had loads of fun with it, and no real issues. But if you are riding them hard and tuning them for more performance, you are going to affect your reliability/longevity. You never get something for nothing
But it is also done at a significant cost. And you will have to have very deep pockets. I made some serious enquiries and left it at that, £1000 for a 10-15% power hike, is serious bit of cash and all to but the bhp I should have at the crank, at the rear wheel. Too rich for me, especially when you take the 'law of diminishing returns' into account. I.e the next £1000 will only get me 5 bhp.
You will never make it as fast as a 1050 RS.
If you need to blow away R80's and R100's then creep up behind them and catch em whilst they are sleeping!
Cheers
Steve Hawkins