The primary concern is having contact between the valves and piston top! With the spark plugs out, carefully rotate the engine by hand and "feel" for any contact. You will definitely know as the engine will be stopped from rotating. Be Careful...
The small timing mark on the crankshaft is hidden by the sprocket. If the sprocket is removed, there's no real issue in lining up the crank n' cam sprocket marks.
I'm trusting to my memory here so hope if I'm speaking out of school someone will chime in...
Carefully rotate the engine so that the right-side piston is at exactly TDC. The dot on the larger camshaft sprocket should be at 12 o'clock. Again, IIRC from my last timing chain replacement adventure.
There's an excellent lesson here, lads. Before pulling off that old timing chain -and with the cam sprocket's timing "dot" at high noon- mark the location of the corresponding crankshaft sprocket tooth. Paint, Sharpie, whatever.