I think it would be in most cases, more economical to just get an R80 engine from an otherwise broken bike and transplant it. The crankshafts are milled and balanced based on the piston weights, so to keep the engine running smoothly you'd be replacing much of the bottom end even if the existing crank and con-rods are "strong enough".
With the r90 - they bored the R75 cylinder out and used the same stroke, but to keep the engine vibrations in check they needed more crankshaft offset mass. They couldn't make the crank sufficiently massive enough to fit in the same gallery space in the cases, so they drilled out parts of the crankshaft and inserted tungsten plugs to achieve the greater mass. It could become a "diminishing returns" kind of exercise, plus with the Nikasil cylinder bores, one can't simply bore out and re-hone the jugs like one can with the old cast iron cylinder liners, so it becomes a wholesale swap of cylinders&pistons&heads, etc.