My experience yesterday was related, after pulling and cleaning the carbs  I set them at 1.5 turns from seated the right cylinder quit working within a minute, glazed the plug. proper setting is .5 to .75 from lightly closed depending on year and model, check your manuals for the proper settings, when it was set properly the plug cleaned itself and performance was restored.  Turning it in leans the engine and opening it up richens the mixture.  Over 1 turn makes for way to much fuel to run properly.  Carb balance is very important for best performance..  That goes way back to twin Strombourgs on an old mini cooper S, pain to tune but went like a bat on 100/130 AVGAS, thats another story and a different life.  Balance using engine vacumn rather than pulling a plug wire on electronic ignition units damage to electronics can happen.